Role of ATP for cytokine-induced murine hepatotoxicity

My special thanks go to my supervisor Prof. Wendel. He did not only provide excellent working facilities and a generous financing of the project, but also enabled this study by his patience, his encouragement and his stimulating ideas. Moreover, he exemplified impressively the successful fusion of science and other aspects of life. (Altana Pharma Konstanz) enabled me to attend conferences, training courses and provided a basis for fruitful discussions of result. I am grateful for this support and the grant supplied by the Graduiertenkolleg. This opportunity greatly extended my scientific horizons and is deeply treasured. Furthermore, I would like to thank PD Dr. J. Schlepper-Schäfer for excellent coordination of the Graduiertenkolleg and PD Dr. C. Schudt for the assessment of this dissertation. I would like to extend my gratitude to Ulla Gebert for generously introducing me in the secrets of the ELISA technique as well as in vivo working and for her excellent expertise and hands-on experience in these fields. This work benefited greatly from collaborations and discussions with a lot of members of the Chair of Biochemical Pharmacology. The good working spirit and the fun we had, contributed a lot to the motivation and the success of this project. I am especially grateful to Dr. Gerald Künstle and Dr. Hannes Hentze, two model collegues for friendship and valuable discussions. Further thanks go to members of the " liver group " , Matthias Kresse and Markus Weiller for their comradeship and support. Dr. Thomas Meergans is gratefully acknowledged for his advice and excellent expertise in molecular biology.